Not usually. There are many criteria that USCIS will review in order to approve or reject an application. Along with the "significant" investment and the ability to provide jobs, the business must be capable of providing you with an income that will allow you and your family to live a lifestyle equivalent to that you enjoyed in your native country. In Florida, that can be as low as $40.000 to $50.000 per year. In general, to meet this requirement, you have to buy a business for $135.000 / $150.000 or more, depending on the type of business. Therefore, if you invest $100.000 the balance has to be financed (see question above). Furthermore, you also need money for the visa attorney, accountant for the due diligence, lawyer, deposits, etc. This averages between $10,000 and $15,000.